Efficacy of a 12.5% Pyriprole Spot-on Solution against Natural Flea (ctenocephalides Felis) Infestations on Dogs

The efficacy of a 12.5% pyriprole spot-on solution against natural flea infestations applied monthly to dogs on three occasions within 60 days was investigated in patients presented at veterinary clinics in Western Australia. Twelve dogs of various breeds, age, weight, and sex were considered in the study. Six were treated with a pyriprole spoton solution and six treated with a fipronil/ (S)-methoprene spot-on solution as positive controls. The number of fleas on each dog was counted 14 (+2) and 30 (+2) days after the first treatment, and 30 (+2) days after the second and third treatments. The geometric mean efficacy of the pyriprole spot-on solution ranged between 100% and 93.8%, and for the fipronil/(S)-methoprene solution between 98.8% and 44.7%. The treatments were well tolerated by the animals. INTRODUCTION Fleas are a major nuisance pest and the most important ectoparasite infesting dogs and their environment all around the world.1 Flea allergic dermatitis is a common dermatological condition in dogs and fleas can transmit a number of pathogenic micro-organisms and parasites.2,3 Pyriprole is a new representative of the phenylpyrazole derivatives with confirmed broad-spectrum activity against induced flea4 and tick4,5 infestations on dogs. The present investigation was conducted to confirm the efficacy of a 12.5 % spot-on solution against natural infestations on dogs presented as patients at two veterinary clinics in Perth, Western Australia and to determine the level of control when administered in monthly intervals on three occasions within a 60-day period. MATERIALS AND METHODS Thirteen dogs of different breeds (Kelpie, Maltese x Shitzu, Pinscher, Kelpie x Labrador, German Shepherd, cross-bred), mixedEFFICACY OF A 12.5% PYRIPROLE SPOT-ON SOLUTION AGAINST NATURAL FLEA (CTENOCEPHALIDES FELIS) INFESTATIONS ON DOGS. Barry Hosking, MPM1 Ben Kaye Smith, 1 Günther Schuele, PhD2 Günther Strehlau, PhD2 Pablo Junquera, PhD3 1 Novartis Animal Health Australasia Pty Limited Yarrandoo R&D Centre Kemps Creek, NSW 2178, Australia 2 Novartis Animal Health Inc. 4058 Basel, Switzerland 3 Vetparcs Gmbh 8044 Zürich, Switzerland